How gene expression in neurons affects learning and memory
Official title: Molecular Regulation of a Transcriptionally Poised State in Neurons and its Role in Learning
Funded at Loyola University Chicago · NIH-10975774 · Data updated 2026-11-12
This study is looking at how brain cells control the genes needed for memory and learning, especially how calcium signals help kickstart the process, so we can better understand why different training methods work better for animals.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | October 30, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $136,321 |
| NIH project number | 7K01MH129760-03 |
| Project ID | NIH-10975774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive decline or memory issues, particularly those related to Alzheimer's disease.
✕Less likely to help
Patients with cognitive impairments not related to transcriptional regulation or those with advanced Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that regulate gene expression in neurons, particularly focusing on a poised transcriptional state that is crucial for memory formation. It explores how calcium signaling influences the release of RNA polymerase II from a paused state, allowing for the production of messenger RNA necessary for learning. By understanding these processes, the research aims to uncover why certain training schedules impact learning efficiency in animals. The study utilizes various biochemical assays and animal models to analyze these transcriptional dynamics.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing memory and learning in individuals with cognitive impairments.
How similar studies have gone: Other research has shown promising results in understanding the molecular basis of memory formation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Greer, Celeste Brittany — Loyola University Chicago
- Study coordinator: Greer, Celeste Brittany
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.