How changes in chromatin help DNA become more accessible
Official title: Chromatin modifications that enhance DNA accessibility
Funded at Northeastern University · NIH-10894115 · Data updated 2026-11-12
This study is looking at how certain proteins help make DNA easier to read in our cells, which could lead to better treatments for cancer and viral infections like HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $500,099 |
| NIH project number | 5R01GM151305-02 |
| Project ID | NIH-10894115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cancer or those affected by HIV.
✕Less likely to help
Patients with conditions unrelated to chromatin modifications or DNA accessibility may not receive any benefit from this research.
What this research studies
This research investigates how specific modifications to chromatin, the material that packages DNA in cells, can enhance the accessibility of DNA for transcription. By studying proteins known as histone chaperones, particularly the FACT complex and others like LEDGF and HDGF2, the research aims to understand their roles in facilitating the reading of DNA by RNA polymerases. The approach involves examining how these proteins interact with nucleosomes and influence the integration of HIV-1 DNA into human chromatin. Patients may benefit from insights gained into these processes, particularly in the context of cancer treatment and viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cancer treatments and managing viral infections by enhancing our understanding of DNA accessibility.
How similar studies have gone: Other research has shown promising results in understanding chromatin dynamics and their implications for disease, suggesting that this approach has potential for success.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Williams, Mark C — Northeastern University
- Study coordinator: Williams, Mark C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.