How cell structure affects programmed cell death
Official title: Cytoskeletal compartmentalization of apoptotic signaling
Funded at University of Connecticut Storrs · NIH-10944665 · Data updated 2026-11-12
This study is looking at how certain proteins help cells decide when to die, especially when they’re damaged, which could lead to new ways to treat diseases by better understanding this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $322,000 |
| NIH project number | 1R01GM155651-01 |
| Project ID | NIH-10944665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to apoptosis dysregulation, such as certain cancers or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to apoptosis or those who are not experiencing issues with programmed cell death may not benefit from this research.
What this research studies
This research investigates the role of the actin cytoskeleton in regulating programmed cell death, particularly in response to DNA damage. The team will explore how specific proteins, known as nucleation factors, influence the formation of actin filaments and their interaction with apoptotic signaling pathways. By understanding these mechanisms, the research aims to uncover how cells manage apoptosis and protect themselves from damage. This could lead to insights into how to manipulate these processes for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing or inhibiting programmed cell death, which is crucial in cancer treatment and other diseases.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding cytoskeletal dynamics can significantly impact our knowledge of apoptosis.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Campellone, Kenneth G — University of Connecticut Storrs
- Study coordinator: Campellone, Kenneth G
Related research
Other NIH-funded projects on the same topics.
-
New sequencing machine to boost veterinary genomics at CVMDL
A new high-throughput DNA/RNA sequencer will be acquired and put into use at the Connecticut Veterinary Medical Diagnostic Laboratory to improve how we study and diagnose animal diseases.
-
How IL-10 changes mast cells in allergic reactions
This work looks at how the immune signal IL-10 changes mast cells and their responses in people with food allergies.
-
Optimizing a just-in-time intervention to help MSM access chemsex harm-reduction services
A smartphone app-driven approach tests personalized, timely support to help men who have sex with men access chemsex harm-reduction services and reduce HIV risk.
-
Understanding how vagus nerve stimulation helps stroke recovery to guide better treatments
This NIH grant uses computer models to figure out how brief, task-timed vagus nerve stimulation affects the brain after stroke and helps movement recovery.
-
Targeting c-Myc DNA with next-generation nucleic acid tools in aggressive B-cell lymphomas
This grant tests a new way to slow or stop aggressive B-cell lymphomas by directly targeting the c-Myc gene in patients and model systems using advanced nucleic acid analogs.
-
Soft, bendable 3D electronics and microfluidic micro-labs for drug screening in engineered tissues
A team at the University of Connecticut is building a soft, 3D electronic and microfluidic platform to grow human organoids and test drugs safely and accurately.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.