How CD70 affects blood vessel health and function
Immuno-Metabolic Regulation of Vascular Dysfunction by CD70
This study is looking at how a protein called CD70 affects blood vessel health, especially for people with heart disease, to find new ways to improve their vascular health and lower their heart risks.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11031714 on NIH RePORTER |
What this research studies
This research investigates the role of CD70, an immune mediator, in regulating the health and function of blood vessels, particularly in the context of atherosclerotic cardiovascular disease. The study aims to understand how immune activation and inflammation contribute to vascular dysfunction, which is a key factor in cardiovascular diseases. By exploring the metabolic pathways influenced by CD70, the research seeks to identify potential new therapies that could improve vascular health and reduce cardiovascular risks for patients. The principal investigator, Dr. Arvind K. Pandey, is focused on developing a deeper understanding of these mechanisms to advance treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerotic cardiovascular disease.
Not a fit: Patients without cardiovascular disease or those with non-atherosclerotic vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve vascular health and reduce the risk of cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in targeting immune mediators for cardiovascular health, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Pandey, Arvind Kant — Brigham and Women's Hospital
- Study coordinator: Pandey, Arvind Kant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.