How CD70 affects blood vessel health and function
Official title: Immuno-Metabolic Regulation of Vascular Dysfunction by CD70
Funded at Brigham and Women's Hospital · NIH-11031714 · Data updated 2026-11-12
This study is looking at how a protein called CD70 affects blood vessel health, especially for people with heart disease, to find new ways to improve their vascular health and lower their heart risks.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $167,400 |
| NIH project number | 1K08HL177156-01 |
| Project ID | NIH-11031714 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerotic cardiovascular disease.
✕Less likely to help
Patients without cardiovascular disease or those with non-atherosclerotic vascular conditions may not benefit from this research.
What this research studies
This research investigates the role of CD70, an immune mediator, in regulating the health and function of blood vessels, particularly in the context of atherosclerotic cardiovascular disease. The study aims to understand how immune activation and inflammation contribute to vascular dysfunction, which is a key factor in cardiovascular diseases. By exploring the metabolic pathways influenced by CD70, the research seeks to identify potential new therapies that could improve vascular health and reduce cardiovascular risks for patients. The principal investigator, Dr. Arvind K. Pandey, is focused on developing a deeper understanding of these mechanisms to advance treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve vascular health and reduce the risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promise in targeting immune mediators for cardiovascular health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Pandey, Arvind Kant — Brigham and Women's Hospital
- Study coordinator: Pandey, Arvind Kant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.