How calcium uptake is regulated during bone development in embryos
Official title: Neural Crest Regulation of Embryonic Calcium Uptake
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11111998 · Data updated 2026-11-12
This study is looking at how a special protein called Sox10 helps embryos, like zebrafish, absorb calcium, which is really important for building strong bones, and it could help us understand more about bone health in general.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $200,625 |
| NIH project number | 1R21HD118147-01 |
| Project ID | NIH-11111998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting bone mineralization or calcium metabolism, particularly those in developmental stages.
✕Less likely to help
Patients with fully developed bone structures and no history of calcium regulation disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which calcium is absorbed during the critical process of bone mineralization in vertebrate embryos. The study focuses on the role of a specific transcription factor, Sox10, which has been found to influence calcium uptake through interactions with an endocrine gland. By examining zebrafish models, the researchers aim to uncover the cellular and molecular pathways that regulate calcium levels, which are essential for proper bone development. This work could provide insights into developmental biology and potential implications for bone health.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of bone development disorders and potential therapeutic strategies for conditions related to calcium regulation.
How similar studies have gone: While the specific role of Sox10 in calcium regulation is novel, similar studies have successfully linked transcription factors to developmental processes in other contexts.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Barske, Lindsey Anne — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Barske, Lindsey Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.