How amphetamines affect brain signaling in addiction
Official title: Synaptic Actions of Amphetamine in the Striatum
Funded at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-11042869 · Data updated 2026-11-12
This study looks at how amphetamines affect the brain's dopamine system, which plays a big role in addiction, to help us understand what happens in the brain during addiction and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $550,811 |
| NIH project number | 5R01DA056584-03 |
| Project ID | NIH-11042869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with addiction to psychostimulants like amphetamines.
✕Less likely to help
Patients who do not have a history of substance use disorders or those not affected by psychostimulant addiction may not benefit from this research.
What this research studies
This research investigates how amphetamines influence dopamine signaling in the striatum, a key brain region involved in addiction. It examines both the fast and slow mechanisms by which amphetamines release dopamine and how this affects various receptors in the brain. By focusing on the synaptic connections between dopamine, GABA, and glutamate, the study aims to understand the changes that occur in the brain's circuitry during addiction. This could provide insights into the underlying mechanisms of addictive behaviors and potential treatment targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating addiction by targeting specific brain signaling pathways.
How similar studies have gone: Previous research has shown promising results in understanding the role of dopamine signaling in addiction, making this approach both relevant and potentially impactful.
Where this research is happening
-
New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
New York, United States Active
Researchers
- Principal investigator: Rayport, Stephen — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Rayport, Stephen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.