How alcohol affects ulcerative colitis symptoms
Official title: IL-22-STAT3-Nos2 axis in alcohol-mediated exacerbation of UC pathology
Funded at Loyola University Chicago · NIH-10869469 · Data updated 2026-11-12
This study looks at how drinking alcohol affects people with ulcerative colitis by making their symptoms worse and increasing the chance of infections, using mice to understand the changes in gut bacteria and inflammation that happen because of alcohol.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | August 22, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $213,000 |
| NIH project number | 1R21AA031560-01 |
| Project ID | NIH-10869469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ulcerative colitis who consume alcohol.
✕Less likely to help
Patients without a diagnosis of ulcerative colitis or those who do not consume alcohol may not benefit from this research.
What this research studies
This research investigates the impact of alcohol consumption on patients with ulcerative colitis (UC), focusing on how it exacerbates symptoms and increases the risk of intestinal infections. The study uses a mouse model to explore the mechanisms behind these effects, particularly looking at changes in gut bacteria and inflammatory responses. By examining the IL-22-STAT3-Nos2 signaling pathway, the research aims to understand how alcohol alters the gut environment and contributes to disease progression. Patients may gain insights into the risks associated with alcohol use in relation to their UC condition.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for ulcerative colitis patients who consume alcohol.
How similar studies have gone: Previous research has indicated that alcohol can worsen gastrointestinal diseases, suggesting that this study builds on established findings rather than exploring a completely novel approach.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Choudhry, Mashkoor a — Loyola University Chicago
- Study coordinator: Choudhry, Mashkoor a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.