How a specific long non-coding RNA affects heart function and calcium handling
Official title: Regulation of gene transcription and alternative splicing by a long non-coding RNA
Funded at University of South Florida · NIH-10918627 · Data updated 2026-11-12
This study is looking at how a specific type of RNA affects heart cells and their ability to handle calcium, which is important for a healthy heart, and it could help us find new ways to treat heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 2, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $506,434 |
| NIH project number | 7R01HL159086-03 |
| Project ID | NIH-10918627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease or those at risk of developing cardiac conditions.
✕Less likely to help
Patients without any cardiac issues or those who do not have a genetic predisposition to heart disease may not benefit from this research.
What this research studies
This research investigates the role of a long non-coding RNA (lncRNA) in regulating gene expression and alternative splicing in heart cells. By studying both human and mouse heart cells, the researchers aim to understand how this lncRNA influences calcium handling, which is crucial for heart function. The project will explore the mechanisms by which the lncRNA affects gene transcription and splicing, as well as its protective effects on the heart under stress conditions. The findings could lead to new treatments for heart disease.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for heart disease, improving outcomes for patients with cardiac conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of lncRNAs in heart function, indicating that this approach has potential for success.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Song, Kunhua — University of South Florida
- Study coordinator: Song, Kunhua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.