How a specific enzyme affects heart function and calcium levels
Official title: Phosphodiesterase 1 (PDE1) Regulation of Myocardial Calcium and Function
Funded at Loyola University Chicago · NIH-11013862 · Data updated 2026-11-12
This study is looking at how a specific enzyme called PDE1 affects heart function and calcium levels in heart muscle, with the goal of finding safer treatments for heart failure that can help the heart pump better without causing irregular heartbeats.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | January 22, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $553,941 |
| NIH project number | 5R01HL171586-02 |
| Project ID | NIH-11013862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing heart failure or related cardiac conditions.
✕Less likely to help
Patients with non-cardiac conditions or those under 21 years old may not receive any benefit from this research.
What this research studies
This research investigates the role of phosphodiesterase 1 (PDE1) in regulating heart function and calcium levels in the heart muscle. The study aims to understand how inhibiting PDE1 can improve cardiac contractility without increasing the risk of arrhythmias, which is a concern with other similar drugs. By examining the mechanisms of action of PDE1 and comparing it to PDE3, the research seeks to uncover how these enzymes influence heart function differently. Patients may benefit from insights that could lead to safer heart failure treatments.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for heart failure that minimize the risk of dangerous side effects.
How similar studies have gone: Previous research has shown that targeting phosphodiesterases can improve heart function, but the specific effects of PDE1 inhibition are still being explored.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Muller, Grace Kim — Loyola University Chicago
- Study coordinator: Muller, Grace Kim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.