HER2/ERBB2 biology in African American men with prostate cancer
Official title: A multiomic analysis of HER2/ERBB2 in African American men with prostate cancer
Funded at Morehouse School of Medicine · NIH-11324283 · Data updated 2026-11-12
This grant supports a study of how the HER2/ERBB2 protein behaves in prostate cancer among African American men to uncover factors that affect disease outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morehouse School of Medicine NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 7, 1997 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $314,706 |
| NIH project number | 5U54MD007602-39 |
| Project ID | NIH-11324283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults of African ancestry with prostate cancer, especially those with metastatic disease or at risk of progression.
✕Less likely to help
Patients without metastatic disease or without African ancestry may have limited relevance to the study aims.
What this research studies
Researchers will use advanced multiomic analyses and 3D cell culture models to study how HER2/ERBB2 contributes to prostate cancer progression in African American men. The work focuses on racial differences in molecular pathways and how they relate to metastasis and treatment resistance. Findings could identify biomarkers and new targets to improve care for men affected by this disease.
Why it matters
Potential benefit: Could lead to more personalized treatments and better outcomes for African American men with metastatic prostate cancer.
How similar studies have gone: Previous studies have linked HER2 signaling to worse prognosis in prostate cancer, but trials with sufficient AA representation are limited, making this work relatively novel.
Where this research is happening
-
Morehouse School of Medicine
Atlanta, United States Active
Researchers
- Principal investigator: Burnham, Leanne — Morehouse School of Medicine
- Study coordinator: Burnham, Leanne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.