Understanding how insulin resistance affects type 2 diabetes and fatty liver disease
Hepatic insulin resistance integrates T2D and NAFLD
This study is looking at how type 2 diabetes can affect liver health, especially when it comes to fatty liver disease, by testing a sugary diet on mice to find out what happens and how we might help people with these conditions in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10980982 on NIH RePORTER |
What this research studies
This research investigates the connection between type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), focusing on how chronic insulin resistance in the liver can lead to severe liver conditions. The study uses a mouse model to explore the effects of a diet similar to common sugary foods and beverages on liver health and insulin function. By examining genetic modifications in mice, the researchers aim to identify specific pathways that worsen these diseases and how they might be targeted for treatment in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes or non-alcoholic fatty liver disease, particularly those showing signs of insulin resistance.
Not a fit: Patients without type 2 diabetes or non-alcoholic fatty liver disease, or those with other unrelated metabolic conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse the progression of type 2 diabetes and fatty liver disease.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms linking insulin resistance with fatty liver disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: White, Morris F. — Boston Children's Hospital
- Study coordinator: White, Morris F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.