Heart and lung health after TB: understanding how TB affects the heart and lungs, especially with HIV
Official title: Heart and Lung Outcomes Post-TB (HALO Post-TB)
Funded at University of California Los Angeles · NIH-11538866 · Data updated 2026-11-12
This NIH grant studies how prior tuberculosis affects heart and lung health, including the impact of HIV, to help people with TB-related health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 25, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $212,175 |
| NIH project number | 3R01HL176528-03S1 |
| Project ID | NIH-11538866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of TB, including those living with HIV in high TB/HIV burden settings.
✕Less likely to help
People without a history of TB or those not affected by cardiopulmonary issues may see little direct benefit.
What this research studies
This study will look at people who have had tuberculosis to see how their lungs and hearts function over time. Researchers will use full pulmonary tests, heart imaging, and fitness tests to understand cardiopulmonary health after TB. They’ll also examine how HIV may change these outcomes. The goal is to map how common these issues are and what factors influence them in settings with high TB and HIV burdens.
Why it matters
Potential benefit: Better understanding of post-TB cardiopulmonary problems could lead to improved screening and targeted care for patients recovering from TB.
How similar studies have gone: Prior post-TB studies have rarely included comprehensive lung and heart testing, so this project advances beyond earlier work.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
Related research
Other NIH-funded projects on the same topics.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Systems genetics of vascular smooth muscle phenotypes in heart disease
Aims to understand how genetic differences influence vascular smooth muscle cells to improve prevention and treatment of coronary artery disease.
-
Motivation for Alcohol Use in Humans and How It Can Be Measured
This grant explores how people are motivated to drink alcohol and tests a safe, controlled way to study that motivation to inform better treatments for alcohol use disorder.
-
Overcoming CAR T cell resistance with tumor-targeted IL-12 to boost anti-tumor immunity
Aims to make CAR T cell therapy work better for solid tumors by using tumor-focused IL-12 to boost the body’s attack on cancer.
-
PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.
-
Mentor Moms+: a community-led plan to cut alcohol use and HIV risk during pregnancy in South Africa
A community-based program adapts a trusted peer-led model to help pregnant and lactating people reduce alcohol use and HIV risk in South Africa.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.