NIH-funded research R01 grant

Hearing and brain function in people with HIV in Tanzania

Official title: Advancing and applying peripheral and central auditory findings in HIV/AIDS.

Funded at Dartmouth College · NIH-11389566 · Data updated 2026-11-12

This project studies how hearing and brain function change over time in people with HIV and similar people without HIV in Tanzania, to see if ear tests can foretell cognitive decline.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionDartmouth College
NIH-funded
Lab location1 site (Hanover, United States)
Project startJuly 1, 2022
Project endJune 30, 2027
Funding year2026
Award (this year)$398,766
NIH project number5R01DC020135-05
Project IDNIH-11389566 on NIH RePORTER

Who could benefit from this research

Could help

Adults with HIV and HIV-uninfected controls in the Ubongo Sikivu cohort who have undergone long-term hearing and cognitive assessments.

Less likely to help

Individuals without HIV or those not in the cohort may not directly benefit from this study.

What this research studies

Researchers are following a long-running group in Tanzania that includes people living with HIV and HIV-negative controls, with regular checks of hearing and brain-related functions. The study uses both ear-specific and central brain tests, along with neurocognitive assessments, to understand how HIV and its treatment affect the auditory system and cognition over time. The team will look at whether changes in central auditory tests can predict future cognitive problems and whether long-term antiretroviral therapy influences these relationships. This work builds on years of data and aims to identify which tests best forecast cognitive decline in PLWH. Results could help tailor monitoring and interventions to protect hearing and brain health in HIV patients.

Why it matters

Potential benefit: If successful, this work could lead to earlier detection of cognitive decline in people with HIV using hearing tests and inform strategies to protect brain health.

How similar studies have gone: Previous work in this cohort has shown that central auditory tests correlate with cognitive performance, supporting further exploration.

Where this research is happening

  • Dartmouth College
    Hanover, United States
    Active

Researchers

  • Principal investigator: Buckey, Jay C — Dartmouth College
  • Study coordinator: Buckey, Jay C

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.