Gut bacteria, colon state, and early colorectal tumor growth
Official title: The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression
Funded at Fred Hutchinson Cancer Center · NIH-11412578 · Data updated 2026-11-12
This grant looks at how the gut microbiome and the lining of the colon work together to influence the formation and growth of early colorectal tumors, with goals to prevent cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 20, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $303,818 |
| NIH project number | 5U54CA274374-05 |
| Project ID | NIH-11412578 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for colorectal adenomas or cancer, and individuals undergoing colonoscopy or with known adenomas.
✕Less likely to help
Individuals without risk factors or not undergoing colorectal screening may be less likely to benefit.
What this research studies
This project explores whether the gut bacteria and a primed colon environment promote adenoma formation. It uses advanced microbiome analysis and studies with mouse models that lack normal gut microbes to understand interactions with a primed colon. The researchers also aim to identify microbiome features in humans that distinguish aggressive from slower-growing adenomas. The long-term goal is to develop microbiome-based strategies to prevent adenomas and colorectal cancer.
Why it matters
Potential benefit: If successful, the work could lead to personalized prevention strategies that reduce the risk of colorectal cancer by targeting the gut microbiome.
How similar studies have gone: Previous studies show links between the gut microbiome and colorectal lesions, with growing evidence supporting microbiome-based prevention approaches.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Dey, Neelendu — Fred Hutchinson Cancer Center
- Study coordinator: Dey, Neelendu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.