Glycemic and metabolic profiling during pregnancy to predict future heart disease risk
Official title: Glycemic Observation and Metabolic Profiling of Mothers in Pregnancy to Predict Cardiovascular Health (GO MOMs Predict)
Funded at Massachusetts General Hospital · NIH-11450457 · Data updated 2026-11-12
A pregnancy-focused study uses blood tests and metabolic data to predict a mom’s risk of cardiovascular disease years after delivery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,401,048 |
| NIH project number | 1R01HL184086-01A1 |
| Project ID | NIH-11450457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are pregnant individuals, especially in the first trimester, who consent to metabolic and health data collection and follow-up after delivery.
✕Less likely to help
Individuals who do not participate in follow-up after delivery or lack access to long-term health monitoring may not benefit.
What this research studies
This project analyzes metabolic and glycemic data collected during pregnancy to build models that forecast cardiovascular risk up to five years after birth. Building on a large multicenter cohort, it aims to identify reliable pregnancy-related markers that improve early risk prediction. The study will test these models in a new group of pregnant individuals to see how well they predict future conditions like high blood pressure, prediabetes/diabetes, and high cholesterol. If successful, the approach could help doctors tailor prevention strategies during and after pregnancy.
Why it matters
Potential benefit: If successful, this work could lead to earlier, personalized prevention of cardiovascular disease for women after pregnancy.
How similar studies have gone: Previous observational work suggests pregnancy-related metabolic signals can inform future CVD risk, but this study tests new predictive models in a large, diverse cohort.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Powe, Camille Elise — Massachusetts General Hospital
- Study coordinator: Powe, Camille Elise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.