Glucose and oxygen metabolism shaping human brain development
Official title: Glucose & oxygen metabolism regulate human cortical progenitor development impacting brain health
Funded at Arizona State University-Tempe Campus · NIH-11447894 · Data updated 2026-11-12
Researchers are studying how changes in sugar and oxygen use influence how the human brain develops, with the goal of understanding factors that could impact conditions like ADHD and autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 5, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $549,397 |
| NIH project number | 1R01NS146341-01A1 |
| Project ID | NIH-11447894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with or at risk for ADHD or autism, or adults interested in understanding how early brain metabolism might relate to current conditions.
✕Less likely to help
People without interest in neurodevelopmental biology or metabolic influences on the brain may not directly benefit.
What this research studies
This project looks at how metabolic processes control when and how brain cells form and organize themselves during development. It uses human cell models or tissues to trace how energy production and fuel use guide cell fate and brain structure. By linking metabolic changes to developmental outcomes, the study aims to identify critical windows where metabolism influences brain health. Findings could reveal metabolic targets for preventing or mitigating neurodevelopmental disorders.
Why it matters
Potential benefit: If successful, the work could highlight metabolic pathways that support healthy brain development and point to new strategies for reducing risk of ADHD or autism related to metabolic factors.
How similar studies have gone: Previous studies have linked metabolism to brain development and neurodevelopmental outcomes, suggesting this approach is promising but complex.
Where this research is happening
-
Arizona State University-Tempe Campus
Scottsdale, United States Active
Researchers
- Principal investigator: Andrews, Madeline — Arizona State University-Tempe Campus
- Study coordinator: Andrews, Madeline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.