Whole Protein Arrays to Find Antibodies Linked to Islet Autoimmunity in a Big Birth Cohort
Official title: Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDY
Funded at Arizona State University-Tempe Campus · NIH-11600224 · Data updated 2026-11-12
This NIH grant aims to map antibodies against many microbes in children from the TEDDY study to understand what infections might be linked to the development of type 1 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $297,392 |
| NIH project number | 3R01DK140781-03S1 |
| Project ID | NIH-11600224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children enrolled in the TEDDY birth cohort who have or are at risk for islet autoimmunity.
✕Less likely to help
Children not at risk for type 1 diabetes or those not in the TEDDY cohort may not directly benefit.
What this research studies
The project uses high-throughput protein arrays to detect antibodies toward a wide range of microbes in a large birth cohort. It combines immunoproteomics with data from the TEDDY study to explore how environmental exposures relate to islet autoimmunity and progression to type 1 diabetes. The team brings expertise in diabetes, virology, metagenomics, and advanced statistics to create a comprehensive view of potential microbial triggers. The goal is to identify broad antibody patterns that could inform prevention strategies for at-risk children.
Why it matters
Potential benefit: If successful, findings could guide future prevention efforts and improve understanding of how infections influence type 1 diabetes risk.
How similar studies have gone: Previous studies have shown associations between infections and autoimmune phenomena, but this project aims for a comprehensive, high-throughput approach in a large prospective cohort.
Where this research is happening
-
Arizona State University-Tempe Campus
Scottsdale, United States Active
Researchers
- Principal investigator: Labaer, Joshua — Arizona State University-Tempe Campus
- Study coordinator: Labaer, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.