Understanding how herpesviruses move and exit cells (focus on HSV-1 and PRV)
Official title: Molecular and cellular mechanisms of HSV-1 assembly and egress
Funded at Arizona State University-Tempe Campus · NIH-11617692 · Data updated 2026-11-12
Scientists are studying how herpesviruses travel inside nerve cells and exit at the right spots, which could lead to better prevention and treatment of infections in people and animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | December 1, 2021 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $50,456 |
| NIH project number | 3R01NS117513-05S1 |
| Project ID | NIH-11617692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals at risk for herpesvirus infections or clinicians seeking new strategies to prevent or treat viral spread to the nervous system.
✕Less likely to help
People without herpesvirus exposure or those not affected by central nervous system involvement may not directly benefit.
What this research studies
This project looks at how alpha herpesviruses like HSV-1 and PRV hijack nerve cell transport to spread inside the body. It uses existing virus tools to test what cellular factors control where the virus exits the cell, and how this happens in non-neuronal cells and neurons. The work involves acute perturbations of specific cellular pathways to see how they affect viral movement and release. The findings could illuminate why these viruses cause brain inflammation and recurrent lesions, potentially guiding new therapies.
Why it matters
Potential benefit: If successful, the research could reveal targets to interrupt viral spread in neurons and reduce severe disease in humans and animals.
How similar studies have gone: Previous work has shown that intracellular transport routes influence herpesvirus spread, supporting potential impact but the exact mechanisms in neurons are still being defined.
Where this research is happening
-
Arizona State University-Tempe Campus
Scottsdale, United States Active
Researchers
- Principal investigator: Hogue, Ian B — Arizona State University-Tempe Campus
- Study coordinator: Hogue, Ian B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.