From Motion to Mechanism: How Cellular Dynamics Shape Molecular Programs and Function In Vivo
Funded at Northeastern University · NIH-11429089 · Data updated 2026-11-12
This grant explores how cells’ movements and signals in living tissues influence molecular programs, aiming to connect dynamic cell behavior with tissue function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $440,000 |
| NIH project number | 1R35GM165835-01 |
| Project ID | NIH-11429089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with conditions involving tissue remodeling, immune responses, or cancer where dynamic cellular behavior is important.
✕Less likely to help
Individuals without diseases related to tissue dynamics or those not undergoing activities where dynamic signaling is relevant may see limited direct benefit.
What this research studies
Researchers developed Image-seq to connect live cell dynamics with spatially resolved molecular data. This project will advance this platform to include proteomic information and deeper tissue penetration, enabling study of dynamic cellular states in more tissues. By linking movement, proliferation, and signaling with molecular profiles in vivo, the work could illuminate how dynamic states drive development, healing, and disease processes.
Why it matters
Potential benefit: If successful, this work could improve understanding of how cellular dynamics shape disease and recovery, potentially guiding new therapies that target dynamic cell behaviors.
How similar studies have gone: Prior work with Image-seq has shown value linking spatial molecular data to cell history; this project extends that approach to proteomics and deeper tissues.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Haase, Christa — Northeastern University
- Study coordinator: Haase, Christa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.