Finding genetic changes that affect human health in large population groups
Official title: Identifying structural variants influencing human health in population cohorts
Funded at Brigham and Women's Hospital · NIH-10889519 · Data updated 2026-11-12
This study is looking at how certain larger genetic changes can affect health, using advanced methods to analyze big sets of genetic data, so we can better understand diseases and create more personalized treatments for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $400,000 |
| NIH project number | 1R56HG012698-01A1 |
| Project ID | NIH-10889519 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals from diverse population cohorts who may have genetic variations influencing their health.
✕Less likely to help
Patients with no significant genetic variations or those not represented in the studied population cohorts may not benefit from this research.
What this research studies
This research aims to uncover genetic structural variants that can influence health by developing new statistical methods to analyze large biobank datasets. By focusing on structural variants, which are larger genetic changes than typical single-nucleotide variations, the study seeks to improve our understanding of how these variants contribute to diseases. The approach involves using haplotype information, which allows researchers to identify shared genetic patterns among individuals in a population, thereby enhancing the accuracy of variant detection. This could lead to more targeted and effective treatments based on individual genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more precise and personalized medical treatments based on genetic information.
How similar studies have gone: Previous research has shown promise in using similar statistical methods to identify genetic variants, suggesting potential for success in this novel approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Loh, Po-Ru — Brigham and Women's Hospital
- Study coordinator: Loh, Po-Ru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.