Global picture of dementia and Alzheimer’s risk across populations
Official title: A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC Collaboration
Funded at University of New South Wales · NIH-11417899 · Data updated 2026-11-12
A large international effort gathers health data from many cohorts to understand what increases or lowers the risk of dementia and Alzheimer's disease around the world.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New South Wales NIH-funded |
| Lab location | 1 site (Sydney, Australia) |
| Project start | September 15, 2017 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,388,358 |
| NIH project number | 5R01AG057531-05 |
| Project ID | NIH-11417899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals across the globe who are part of the COSMIC cohorts or similar aging populations may contribute data or participate in future related studies.
✕Less likely to help
Direct clinical benefits may not be immediate for any single patient, as this is a large epidemiological collaboration.
What this research studies
COSMIC brings together dozens of long-term studies from many countries to analyze how dementia develops and what factors influence it, using harmonized data so researchers can combine results. The project plans pooled analyses and meta-analyses of individual participant data to map modifiable risk factors and pre-dementia conditions. By studying diverse populations, including LMICs, it aims to identify patterns that could guide prevention and early diagnosis. The work is data-driven and collaborative, building a global resource for understanding cognitive aging.
Why it matters
Potential benefit: If successful, the findings could inform public health strategies to prevent dementia and support earlier diagnosis.
How similar studies have gone: Previous large-scale harmonized cohort analyses have revealed important risk patterns, suggesting this approach can yield actionable insights.
Where this research is happening
-
University of New South Wales
Sydney, Australia Active
Researchers
- Principal investigator: Sachdev, Perminder S — University of New South Wales
- Study coordinator: Sachdev, Perminder S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.