Exploring ways to reverse aging at the cellular level
Official title: Understanding the cellular time machine that enables rejuvenation
Funded at University of California Los Angeles · NIH-11073849 · Data updated 2026-11-12
This study is exploring new ways to help older cells and tissues feel young again by using special proteins, which could improve how our organs work and even help reverse some effects of aging, with hopes of developing treatments for people as we all get older.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $422,419 |
| NIH project number | 1R21AG092008-01 |
| Project ID | NIH-11073849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or decline in organ function.
✕Less likely to help
Patients who are not aged or do not exhibit age-related conditions may not benefit from this research.
What this research studies
This research investigates innovative methods to rejuvenate aging cells and tissues using specific transcription factors that can reset their epigenetic profiles. By employing techniques like in vivo cellular reprogramming, the study aims to enhance organ function and potentially reverse age-related decline. Initial experiments have shown promising results in aged mice, including improved muscle regeneration and better glucose tolerance. The goal is to translate these findings into potential therapies for humans as the aging population grows.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking treatments that significantly improve health and quality of life for older adults.
How similar studies have gone: Other research has shown success with similar cellular reprogramming approaches, indicating a promising avenue for rejuvenation therapies.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Plath, Kathrin — University of California Los Angeles
- Study coordinator: Plath, Kathrin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.