Exploring shared cancer targets through splicing neoantigens
Official title: Pancancer discovery and exploration of shared splicing neoantigens
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11113044 · Data updated 2026-11-12
This study is exploring a new way to help cancer patients by finding special targets in tumors that can boost the effectiveness of immunotherapy, using smart computer tools to identify these targets in different types of cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $225,101 |
| NIH project number | 1R21CA300922-01 |
| Project ID | NIH-11113044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with various types of cancer who may benefit from novel immunotherapy approaches.
✕Less likely to help
Patients with cancers that do not involve alternative splicing or those who are not eligible for immunotherapy may not receive benefits from this research.
What this research studies
This research investigates the potential of splicing neoantigens as new targets for cancer immunotherapy. By utilizing advanced artificial intelligence techniques, the team aims to identify common immunogenic targets that arise from alternative RNA splicing in various cancers. The approach involves developing a computational tool called Splicing Neoantigen Finder (SNAF) to predict and validate these neoantigens, which could lead to more effective treatments for a broader range of cancer patients. The research focuses on both solid tumors and hematological malignancies, aiming to enhance the efficacy of immunotherapies.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective immunotherapies for a wider range of cancer patients.
How similar studies have gone: Other research has shown promise in targeting neoantigens for cancer therapy, suggesting that this approach could be a significant advancement in the field.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Salomonis, Nathan G. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Salomonis, Nathan G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.