Exploring how THC affects brain function and memory.
Official title: Multimodal magnetoencephalography and electroencephalography exploration of the acute effects of THC exposure on neural noise and information transmission within working memory networks
Funded at Yale University · NIH-10453350 · Data updated 2026-11-12
This study is looking at how THC, the active part of cannabis, affects brain activity and thinking skills, and it's for people who are curious about how cannabis might change their brain function.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $196,350 |
| NIH project number | 1R03DA054453-01A1 |
| Project ID | NIH-10453350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are non-users of cannabis who are interested in understanding the effects of THC on brain function.
✕Less likely to help
Patients who regularly use cannabis or have a history of substance abuse may not benefit from this research.
What this research studies
This research investigates the immediate effects of THC, the psychoactive component of cannabis, on brain activity and cognitive function. Using advanced techniques like magnetoencephalography (MEG) and electroencephalography (EEG), the study will assess how THC alters neural connectivity and information processing in the brain. Participants will undergo a double-blind, placebo-controlled trial, where they will receive either THC or a placebo on different days, allowing researchers to compare the effects on their cognitive performance and brain activity.
Why it matters
Potential benefit: If successful, this research could provide insights into the cognitive risks associated with THC use, helping to inform public health guidelines and individual choices regarding cannabis consumption.
How similar studies have gone: This approach is novel, as it is the first study to utilize MEG/EEG to examine the acute effects of THC on brain activity and cognition.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Cortes-Briones, Jose a — Yale University
- Study coordinator: Cortes-Briones, Jose a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.