Exploring how exercise affects brain energy function in Alzheimer's disease
Official title: Next generation metabolic imaging of the effect of exercise on mitochondrial function in Alzheimer's disease
Funded at Massachusetts General Hospital · NIH-10889598 · Data updated 2026-11-12
This study is looking at how exercise can help improve brain and heart health in people with Alzheimer's disease, and it invites older adults to join in and see how staying active might slow down the effects of the condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $332,096 |
| NIH project number | 1R03AG087483-01 |
| Project ID | NIH-10889598 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who are living with Alzheimer's disease.
✕Less likely to help
Patients who are not diagnosed with Alzheimer's disease or those who are unable to participate in exercise may not benefit from this research.
What this research studies
This research investigates the impact of exercise on mitochondrial function in individuals with Alzheimer's disease. By utilizing advanced metabolic imaging techniques, the study aims to understand how physical activity influences brain and heart health in older adults. Participants will engage in exercise regimens while their metabolic responses are monitored, providing insights into the relationship between cardiovascular health and cognitive function. The goal is to identify lifestyle changes that could potentially slow the progression of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new lifestyle recommendations that help slow down the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results regarding the benefits of exercise on cognitive function in older adults, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Yen, Yi-Fen — Massachusetts General Hospital
- Study coordinator: Yen, Yi-Fen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.