Exploring how a specific signaling pathway affects Alzheimer's Disease using stem cells
Official title: Investigating the role of the fractalkine axis in Alzheimer's Disease pathology using human induced pluripotent stem cells
Funded at Indiana University Indianapolis · NIH-11221029 · Data updated 2026-11-12
This study is looking at how a specific communication system in the brain affects Alzheimer's Disease by using special human cells, hoping to find new ways to help people with the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | May 27, 2024 |
| Project end | May 26, 2027 |
| Funding year | 2025 |
| Award (this year) | $43,350 |
| NIH project number | 5F30AG084304-02 |
| Project ID | NIH-11221029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or those at risk due to genetic factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's Disease may not benefit from this research.
What this research studies
This research investigates the role of the fractalkine signaling pathway in the pathology of Alzheimer's Disease (AD) by utilizing human induced pluripotent stem cells. The study focuses on understanding how communication between microglia, the brain's immune cells, and neurons influences neurodegeneration associated with AD. By examining the interactions through the CX3CR1/CX3CL1 axis, the research aims to uncover mechanisms that contribute to the disease, which have been inadequately addressed in traditional mouse models. This approach seeks to provide insights that could lead to more effective therapeutic strategies for AD patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating Alzheimer's Disease.
How similar studies have gone: Previous research has shown promise in understanding neurodegeneration through similar signaling pathways, but this approach using human stem cells is relatively novel.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Tutrow, Kaylee — Indiana University Indianapolis
- Study coordinator: Tutrow, Kaylee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.