NIH-funded research R01 grant

Executive Function Training in Older Adults: What Helps It Work

Official title: Mediators and Moderators of Executive Function Training in Older Adults

Funded at Northeastern University · NIH-11398936 · Data updated 2026-11-12

This grant tests how different ways of delivering brain-training exercises affect older adults, including those at risk for Alzheimer’s disease, to see what helps people stick with training and improve thinking skills.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNortheastern University
NIH-funded
Lab location1 site (Boston, United States)
Project startSeptember 1, 2025
Project endAugust 31, 2030
Funding year2026
Award (this year)$601,914
NIH project number5R01AG089508-02
Project IDNIH-11398936 on NIH RePORTER

Who could benefit from this research

Could help

Adults aged 60+ who are at risk for ADRD or with age-related cognitive concerns may be eligible.

Less likely to help

Individuals without access to training resources or those not interested in cognitive training may see limited direct benefit.

What this research studies

The project plans to enroll 1,250 adults aged 60 and older to compare various executive function training approaches (single vs multicomponent, standard vs gamified, and standard vs added coaching). Researchers will collect a large, open dataset to measure adherence, engagement, and multiple outcomes related to executive function. By using common outcome measures across training types, the study aims to identify which ingredients make training more reliable and valid. The work addresses the gap between promising lab results and real-world use in older adults who may be at risk for ADRD. If successful, findings could guide practical brain-training programs that people can realistically follow at home or in clinics.

Why it matters

Potential benefit: If successful, the study could reveal which training approaches best support adherence and improve executive function in older adults, potentially helping people maintain cognitive skills longer.

How similar studies have gone: Previous work shows mixed results; this project aims to clarify which training ingredients work best across many participants.

Where this research is happening

  • Northeastern University
    Boston, United States
    Active

Researchers

  • Principal investigator: Jaeggi, Susanne M — Northeastern University
  • Study coordinator: Jaeggi, Susanne M

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.