Evaluating high-risk coronary artery plaque using advanced imaging techniques
Official title: Multi-modality evaluation of high-risk coronary atherosclerotic plaque
Funded at Case Western Reserve University · NIH-10984628 · Data updated 2026-11-12
This study is looking at new ways to spot dangerous plaque in your heart arteries using advanced imaging techniques, so we can help people at risk for heart disease get the care they need earlier and more safely.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $129,612 |
| NIH project number | 1K01HL171795-01A1 |
| Project ID | NIH-10984628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for coronary artery disease, such as those with a family history of heart disease, diabetes, or high cholesterol.
✕Less likely to help
Patients with established coronary artery disease who are not at high risk for further complications may not benefit from this research.
What this research studies
This research focuses on improving the detection of high-risk coronary atherosclerotic plaques, which are critical in preventing cardiovascular disease, the leading cause of death in the US. The study employs advanced imaging techniques, including non-invasive coronary computed tomography angiography (CCTA) and intravascular optical coherence tomography (IVOCT), to identify and assess these dangerous plaques. By developing new artificial intelligence methods to analyze CCTA images, the research aims to provide a safer and more effective way to evaluate coronary artery health without the invasiveness of traditional methods. This could lead to earlier interventions and better management of patients at risk for heart disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of coronary artery disease, ultimately reducing the risk of heart attacks and other serious complications.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for assessing coronary artery disease, indicating that this approach could lead to significant advancements in patient care.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Lee, Juhwan — Case Western Reserve University
- Study coordinator: Lee, Juhwan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.