Enhanced endothelial coating on a flow diverter to prevent brain aneurysm rupture
Official title: Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms
Funded at Endomimetics, LLC · NIH-11418933 · Data updated 2026-11-12
A tiny coating is being tested on a flow-diverter device to help blood vessels heal faster and reduce the chance of brain aneurysm rupture.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomimetics, LLC NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 15, 2019 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $665,292 |
| NIH project number | 5R44NS110114-04 |
| Project ID | NIH-11418933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this preclinical/industrial grant as described; future trials would involve patients with intracranial aneurysms.
✕Less likely to help
Patients would not directly benefit from this preclinical phase until later clinical testing.
What this research studies
This project tests a bioactive coating on a flow diverter used in the brain to block aneurysms. The coating releases a small amount of nitric oxide and includes a cell-friendly ligand to help endothelial cells grow over the device quickly. The goal is to shorten the period when patients must rely on blood thinners and to lower the risk of complications while the aneurysm heals. The work is conducted in a Phase II SBIR setting and involves preclinical studies to show the coating’s safety and its potential to promote faster, more stable endothelial coverage. Collaboration with an industrial sponsor (EndoMimetics, LLC) aims to translate this coating toward clinical use.
Why it matters
Potential benefit: If successful, patients could have a safer, more durable repair of brain aneurysms with fewer bleeding risks.
How similar studies have gone: Similar endothelial-mimicking coatings are being explored, with some evidence suggesting improved healing and reduced clotting risk in device-timed contexts.
Where this research is happening
-
Endomimetics, LLC
Birmingham, United States Active
Researchers
- Principal investigator: Sherwood, Jennifer — Endomimetics, LLC
- Study coordinator: Sherwood, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.