Nanomatrix-coated flow diverter to speed healing of brain aneurysms
Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms
A peptide-based nanomatrix coating for flow-diverter devices is being developed to help people with brain aneurysms heal faster and reduce time on strong blood thinners.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomimetics, LLC NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11192374 on NIH RePORTER |
What this research studies
This project creates a BionanomatrixTM peptide coating for flow-diverter implants used to treat intracranial (brain) aneurysms. The coating slowly releases nitric oxide and includes adhesive signals to recruit and hold endothelial cells so the vessel surface can regrow over the device. Devices are coated using a gentle water-evaporation method designed to limit inflammation, and the team will test performance in laboratory and preclinical models before moving toward clinical use. The goal is faster aneurysm closure and fewer clotting or bleeding complications tied to prolonged antiplatelet therapy.
Who could benefit from this research
Good fit: Adults with unruptured intracranial (cerebral) aneurysms who are candidates for treatment with flow-diverter devices would be the likely participants.
Not a fit: People with ruptured aneurysms, patients who are not treated with flow diverters, or those unable to receive vascular implants are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, the coating could speed vessel healing, lower risks of clotting and bleeding, and shorten the need for dual antiplatelet medication.
How similar studies have performed: Laboratory and animal studies of nitric-oxide–releasing and endothelial-promoting surface coatings have shown promise, but widespread success in human trials has not yet been established.
Where this research is happening
Birmingham, United States
- Endomimetics, LLC — Birmingham, United States (Active)
Researchers
- Principal investigator: Sherwood, Jennifer — Endomimetics, LLC
- Study coordinator: Sherwood, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.