Improving knee joint implants to reduce infections and inflammation
Official title: Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants
Funded at Endomimetics, LLC · NIH-10822220 · Data updated 2026-11-12
This study is looking at a new way to make knee implants better for people with osteoarthritis by adding a special coating that helps prevent infections and swelling after surgery, so patients can heal faster and feel better.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomimetics, LLC NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $292,643 |
| NIH project number | 1R43AR083762-01 |
| Project ID | NIH-10822220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from osteoarthritis who are considering total knee arthroplasty.
✕Less likely to help
Patients who have already undergone knee joint replacement surgery or those with conditions unrelated to osteoarthritis may not benefit from this research.
What this research studies
This research focuses on enhancing knee joint implants used in total knee arthroplasty (TKA) for patients with osteoarthritis. It aims to develop a special coating that releases nitric oxide and antibiotics to prevent infections and reduce inflammation after surgery. By addressing these common complications, the study seeks to improve patient outcomes and quality of life. The approach involves creating and testing a new type of liposome that can deliver these therapeutic agents effectively.
Why it matters
Potential benefit: If successful, this research could lead to fewer infections and complications for patients undergoing knee joint replacement surgery.
How similar studies have gone: While there have been advancements in knee implant technology, this specific approach using multifunctional coatings is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Endomimetics, LLC
Birmingham, United States Active
Researchers
- Principal investigator: Sherwood, Jennifer — Endomimetics, LLC
- Study coordinator: Sherwood, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.