Improving knee joint implants to reduce infections and inflammation
Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants
['FUNDING_SBIR_1'] · ENDOMIMETICS, LLC · NIH-10822220
This study is looking at a new way to make knee implants better for people with osteoarthritis by adding a special coating that helps prevent infections and swelling after surgery, so patients can heal faster and feel better.
Quick facts
| Phase | ['FUNDING_SBIR_1'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ENDOMIMETICS, LLC (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10822220 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing knee joint implants used in total knee arthroplasty (TKA) for patients with osteoarthritis. It aims to develop a special coating that releases nitric oxide and antibiotics to prevent infections and reduce inflammation after surgery. By addressing these common complications, the study seeks to improve patient outcomes and quality of life. The approach involves creating and testing a new type of liposome that can deliver these therapeutic agents effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from osteoarthritis who are considering total knee arthroplasty.
Not a fit: Patients who have already undergone knee joint replacement surgery or those with conditions unrelated to osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to fewer infections and complications for patients undergoing knee joint replacement surgery.
How similar studies have performed: While there have been advancements in knee implant technology, this specific approach using multifunctional coatings is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
BIRMINGHAM, UNITED STATES
- ENDOMIMETICS, LLC — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHERWOOD, JENNIFER — ENDOMIMETICS, LLC
- Study coordinator: SHERWOOD, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.