Improving the safety of devices used to treat brain aneurysms
Official title: Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms
Funded at Endomimetics, LLC · NIH-11008596 · Data updated 2026-11-12
This study is testing a new type of flow diverter for people with unruptured cerebral aneurysms, which has a special coating to help heal faster and reduce risks like blood clots, making treatment safer and more effective.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomimetics, LLC NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 15, 2019 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $920,119 |
| NIH project number | 2R44NS110114-02A1 |
| Project ID | NIH-11008596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with unruptured cerebral aneurysms who may require treatment to prevent rupture.
✕Less likely to help
Patients with ruptured cerebral aneurysms or those who do not have aneurysms may not benefit from this research.
What this research studies
This research focuses on enhancing a device called a flow diverter, which is used to treat unruptured cerebral aneurysms. The device is coated with a special material that mimics the natural lining of blood vessels, promoting faster healing and reducing complications. By releasing nitric oxide, the coating helps attract and retain the cells necessary for healing, potentially leading to quicker closure of the aneurysm. This approach aims to minimize the risks associated with current treatments, such as blood clots and bleeding.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients with cerebral aneurysms, reducing the risk of rupture and improving recovery outcomes.
How similar studies have gone: Previous research has shown promise in using similar coating technologies to enhance medical devices, indicating potential for success in this novel approach.
Where this research is happening
-
Endomimetics, LLC
Birmingham, United States Active
Researchers
- Principal investigator: Sherwood, Jennifer — Endomimetics, LLC
- Study coordinator: Sherwood, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.