NIH-funded research R01 grant

Efficient control of brain signals to improve perceptual decisions

Official title: CRCNS: Efficient control of behavioral and neural variability during perceptual decision-making

Funded at Harvard Medical School · NIH-11538108 · Data updated 2026-11-12

This project tests whether people can reduce neural and behavioral noise during quick, uncertain perceptual decisions by using motivated control of sensory processing.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionHarvard Medical School
NIH-funded
Lab location1 site (Boston, United States)
Project startSeptember 1, 2026
Project endJuly 31, 2030
Funding year2026
Award (this year)$241,873
NIH project number1R01DA067964-01
Project IDNIH-11538108 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are adults with normal or corrected vision who can participate in MEG experiments and perform perceptual decision tasks.

Less likely to help

Individuals unable to participate in brain-imaging studies or with conditions affecting MEG measurements may not benefit.

What this research studies

The study will combine ideas about how the brain limits mental effort with models of perceptual decisions under uncertainty. Researchers will develop normative theories about how people might control the amount of noise in sensory evidence, balancing performance gains against effort costs. They will test predictions in human participants performing decision tasks while measuring brain activity with MEG to see how neural patterns evolve over time. The team will compare observed brain signals to model predictions to understand when and how people exert control to improve decisions. This work could reveal how motivation and beliefs shape perception at the neural level.

Why it matters

Potential benefit: If successful, the research could lead to better ways to enhance decision-making in situations with uncertain information by leveraging motivational strategies.

How similar studies have gone: Past work shows that motivation can influence decision performance, but this project tests precise neural mechanisms of control in perception.

Where this research is happening

  • Harvard Medical School
    Boston, United States
    Active

Researchers

  • Principal investigator: Drugowitsch, Jan — Harvard Medical School
  • Study coordinator: Drugowitsch, Jan

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.