Ecological Core for Tumor Microenvironment Modeling
Official title: Core 2: Ecological Core
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11416453 · Data updated 2026-11-12
A cancer research grant supporting computational and imaging work to understand how tumors interact with their surrounding tissue over time, with a focus on non-small cell lung cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $238,690 |
| NIH project number | 5U54CA274507-04 |
| Project ID | NIH-11416453 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with non-small cell lung cancer whose tissue samples can be analyzed with high-resolution imaging and spatial analyses.
✕Less likely to help
Patients not contributing tissue samples or participating in imaging analyses may not directly benefit.
What this research studies
This project uses advanced spatial analyses and high-resolution tissue images to study how tumor cells and their environment change together over time. It will develop and apply ecological models to predict tumor behavior and response to therapy. The Core will manage, visualize, store, and analyze complex histology data to tailor tools for specific NSCLC projects. The work aims to improve our ability to forecast tumor progression and therapeutic outcomes by examining spatial and temporal patterns in the tumor microenvironment.
Why it matters
Potential benefit: If successful, patients with NSCLC could benefit from better predictions of how their tumors evolve and respond to treatment through more precise monitoring and personalized strategies.
How similar studies have gone: Other studies using spatial and ecological modeling in cancer have shown promise in understanding tumor microenvironments, with growing evidence of value for predicting progression.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Brown, Joel — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Brown, Joel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.