Early-Phase Psychosis: Practice-Based Research to Improve Treatment Outcomes
Funded at Feinstein Institute for Medical Research · NIH-11362312 · Data updated 2026-11-12
A coordinated effort to improve care for people experiencing first-episode psychosis by using learning-health-system tools and real-world clinics.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | June 2, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,503,322 |
| NIH project number | 5P01MH139136-02 |
| Project ID | NIH-11362312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals experiencing a first episode of psychosis who are treated in community clinics using the NAVIGATE model.
✕Less likely to help
Patients not enrolled in NAVIGATE-trained clinics or those outside participating sites may not benefit directly.
What this research studies
This grant builds on NAVIGATE CSC care models for first-episode psychosis and uses an ESPRITO EPINET framework to enroll thousands of participants across diverse community settings. It emphasizes data-driven care, measurement-based practices, and enhanced dashboards to help clinics improve treatment outcomes. The project supports ongoing training for clinic staff and uses central data management to share CAB assessments with a coordinating center. The goal is to refine and scale practical, real-world strategies that improve recovery and functioning for patients in varied communities.
Why it matters
Potential benefit: If successful, patients with first-episode psychosis could receive more timely, personalized care and better overall outcomes through improved, data-guided treatment in real-world clinics.
How similar studies have gone: Prior NAVIGATE and EPINET experiences suggest that learning-health-system approaches can improve care delivery and outcomes in FEP settings.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Robinson, Delbert G — Feinstein Institute for Medical Research
- Study coordinator: Robinson, Delbert G
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.