Early-Phase Psychosis Care: Improving Treatment Outcomes Through Practice-Based Research
Official title: Early-Phase Psychosis: Practice-Based Research to Improve Treatment Outcomes-Administrative Core
Funded at Feinstein Institute for Medical Research · NIH-11362314 · Data updated 2026-11-12
A patient-focused program to improve first-episode psychosis care by learning from real-world clinics and sharing better ways to treat and support people.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | June 2, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $840,365 |
| NIH project number | 5P01MH139136-02 |
| Project ID | NIH-11362314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals experiencing a first episode of psychosis receiving NAVIGATE-style care in participating community clinics.
✕Less likely to help
Patients outside the participating clinics or settings may not directly benefit.
What this research studies
This grant supports expanding and optimizing NAVIGATE-based care for people experiencing a first episode of psychosis across multiple real-world clinics. The team will recruit additional participants, collect standardized assessments, and provide ongoing training to site staff to use data-driven care improvements. The project emphasizes a learning health system approach, using dashboards and data visualization to guide care decisions and improve outcomes in diverse geographic settings. It builds on prior NAVIGATE and ESPRITO EPINET work to accelerate high-quality, coordinated care in community settings.
Why it matters
Potential benefit: Patients with first-episode psychosis could receive more timely, coordinated and effective treatment through enhanced care models and data-driven improvements.
How similar studies have gone: Previous NAVIGATE/EPINET work has demonstrated improvements in care processes within learning health systems, with ongoing expansion showing promise.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Robinson, Delbert G — Feinstein Institute for Medical Research
- Study coordinator: Robinson, Delbert G
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.