Developing safer aminoglycoside antibiotics
Official title: Aminoglycosides with reduced ototoxicity
Funded at Nubad, LLC · NIH-10788273 · Data updated 2026-11-12
This study is working on new antibiotics that can fight serious bacterial infections without risking hearing loss, making it a safer option for patients, especially in hospitals where antibiotic resistance is a big concern.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nubad, LLC NIH-funded |
| Lab location | 1 site (Greer, United States) |
| Project start | August 1, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $999,707 |
| NIH project number | 5R42AI126874-05 |
| Project ID | NIH-10788273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from serious bacterial infections, particularly those caused by multidrug-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by bacteria susceptible to aminoglycosides may not benefit from this research.
What this research studies
This research focuses on creating new aminoglycoside antibiotics that are effective against bacterial infections while minimizing the risk of ototoxicity, which can lead to hearing loss. The team will utilize innovative methods to identify and develop these antibiotics by targeting ribosomal components in bacteria, effectively stopping their growth without harming the patient's hearing. By addressing the growing issue of antibiotic resistance, particularly in hospital settings, this research aims to provide safer treatment options for patients with serious bacterial infections.
Why it matters
Potential benefit: If successful, this research could lead to aminoglycoside antibiotics that are both effective against infections and have a significantly reduced risk of causing hearing loss.
How similar studies have gone: While aminoglycosides have been used for decades, this approach to reducing ototoxicity is innovative and has not been extensively tested in previous research.
Where this research is happening
-
Nubad, LLC
Greer, United States Active
Researchers
- Principal investigator: Arya, Dev Priya — Nubad, LLC
- Study coordinator: Arya, Dev Priya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.