Developing new antibiotics to combat drug-resistant infections
Official title: A biophysical assay targeting Gyrase RNA
Funded at Nubad, LLC · NIH-10608205 · Data updated 2026-11-12
This study is working on new antibiotics to help fight infections that are hard to treat because bacteria have become resistant to current medicines, so patients can have better options for their health.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nubad, LLC NIH-funded |
| Lab location | 1 site (Greer, United States) |
| Project start | April 11, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $226,497 |
| NIH project number | 5R43AI170191-02 |
| Project ID | NIH-10608205 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from bacterial infections that are resistant to current antibiotic treatments.
✕Less likely to help
Patients with viral infections or those who do not have bacterial infections may not benefit from this research.
What this research studies
This research focuses on creating innovative antibiotics to address the growing problem of antimicrobial resistance, which threatens our ability to treat common infections. The project aims to develop a biophysical assay that targets Gyrase RNA, a crucial component in bacterial cell function. By understanding how to inhibit this target, the researchers hope to create new classes of antibiotics that are effective against resistant strains of bacteria. Patients may benefit from improved treatment options for infections that are currently difficult to manage due to resistance.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat drug-resistant bacterial infections.
How similar studies have gone: Other research has shown promise in developing new antibiotics targeting similar mechanisms, indicating that this approach could be viable.
Where this research is happening
-
Nubad, LLC
Greer, United States Active
Researchers
- Principal investigator: Story, Sandra Paige — Nubad, LLC
- Study coordinator: Story, Sandra Paige
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.