Developing new therapies for chronic obstructive lung disease
Official title: Targeting Underlying Pathophysiological Mechanisms to Develop Novel Therapies for Chronic Obstructive Lung Disease
Funded at Mayo Clinic Rochester · NIH-10852821 · Data updated 2026-11-12
This study is looking into how certain harmful substances in the body affect people with COPD, with the goal of finding new treatments that can help improve breathing and keep patients out of the hospital.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | November 11, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $608,962 |
| NIH project number | 5R01HL153407-06 |
| Project ID | NIH-10852821 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease, particularly those experiencing severe symptoms or frequent exacerbations.
✕Less likely to help
Patients with mild or early-stage COPD who do not require advanced therapies may not receive significant benefits from this research.
What this research studies
This research focuses on chronic obstructive pulmonary disease (COPD), a condition that causes airflow obstruction and increases the risk of respiratory infections. The team aims to understand the underlying mechanisms of COPD, particularly how reactive oxygen species and mitochondrial dysfunction contribute to the disease. By investigating these factors, they hope to develop novel therapies that can improve lung function and reduce hospitalizations for patients. The research involves both laboratory studies and potential clinical applications to address the unmet needs in COPD treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the quality of life and health outcomes for patients with COPD.
How similar studies have gone: Previous research has shown promise in targeting similar underlying mechanisms in COPD, but this specific approach is novel and aims to fill a significant gap in current treatment options.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Zahid, Maliha — Mayo Clinic Rochester
- Study coordinator: Zahid, Maliha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.