Developing new methods for creating carbon-carbon bonds using palladium catalysts
Official title: Regiodivergent Palladium-Catalyzed Decarboxylative Coupling of Stabilized Benzylic Nucleophiles
Funded at Occidental College · NIH-10731034 · Data updated 2026-11-12
This study is looking at a way to make a special chemical reaction better, which helps create important small molecules used in medicine, and it's especially for scientists who want to use a wider variety of ingredients in their drug-making processes.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Occidental College NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $341,831 |
| NIH project number | 1R15GM151690-01 |
| Project ID | NIH-10731034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals involved in pharmaceutical development or those with conditions that could be treated by new medications derived from improved synthesis methods.
✕Less likely to help
Patients who are not involved in pharmaceutical development or do not require new drug therapies may not see direct benefits from this research.
What this research studies
This research focuses on improving the palladium-catalyzed decarboxylative allylic alkylation (DAA) reaction, which is essential for synthesizing bioactive small molecules in medicine. The team aims to expand the types of nucleophiles that can be used in this reaction, particularly those that are less stable and have higher pKa values. By utilizing aromatic anions to stabilize these nucleophiles, the researchers hope to enhance the efficiency and versatility of carbon-carbon bond formation, which is crucial for drug development.
Why it matters
Potential benefit: If successful, this research could lead to more efficient methods for synthesizing important medicinal compounds, potentially improving drug development processes.
How similar studies have gone: While palladium-catalyzed reactions are well-established, this specific approach to utilizing aromatic anions for stabilizing nucleophiles is relatively novel and has not been extensively tested.
Where this research is happening
-
Occidental College
Los Angeles, United States Active
Researchers
- Principal investigator: Navarro, Raul — Occidental College
- Study coordinator: Navarro, Raul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.