Developing new methods to create carbon-carbon bonds using light
Photocatalyzed and Enantioselective Umpolung C-C Bond Forming Reactions of Carbonyls
['FUNDING_R15'] · OCCIDENTAL COLLEGE · NIH-11043961
This study is exploring new ways to create important chemical connections using light and safe materials, which could help in developing better drugs and other useful compounds for people.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OCCIDENTAL COLLEGE (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11043961 on ClinicalTrials.gov |
What this research studies
This research focuses on creating innovative methods for forming carbon-carbon bonds, which are essential in organic chemistry. It aims to utilize visible light and benign reagents to generate radical species from ketone-containing compounds, allowing for efficient and environmentally friendly chemical reactions. The approach involves photocatalytic electron transfer to facilitate these reactions, with specific goals including the generation of ketyl radicals and electrophilic radicals for various carbon-carbon bond forming reactions. Patients may benefit from advancements in drug development and synthesis of biologically relevant compounds resulting from these methods.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals involved in pharmaceutical development or those with conditions that could be treated by new drug formulations derived from these chemical processes.
Not a fit: Patients with conditions unrelated to the development of new chemical synthesis methods may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more efficient and sustainable methods for synthesizing important pharmaceutical compounds.
How similar studies have performed: While the specific approach of using visible light for carbon-carbon bond formation is innovative, similar methodologies in organic synthesis have shown promise in other studies.
Where this research is happening
LOS ANGELES, UNITED STATES
- OCCIDENTAL COLLEGE — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CANNON, JEFFREY — OCCIDENTAL COLLEGE
- Study coordinator: CANNON, JEFFREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.