Developing a universal flu vaccine for older adults
Official title: Harnessing Age-Associated B cells for a Universal Influenza Vaccine for the Aged
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10734078 · Data updated 2026-11-12
This study is looking at a new flu vaccine made just for older adults to help boost their immune system, focusing on special B cells that can fight off the flu on their own, so they can stay healthier and better protected against different strains of the virus.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | November 3, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $209,375 |
| NIH project number | 5R21AI173593-02 |
| Project ID | NIH-10734078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and above, who are at higher risk for influenza complications.
✕Less likely to help
Patients who are younger than 65 or those who do not have a compromised immune system may not benefit from this research.
What this research studies
This research focuses on creating a universal influenza vaccine specifically designed for older adults, who often have weakened immune responses. It investigates a unique type of B cell that can generate effective antibodies against influenza, even in the absence of help from other immune cells. By studying how these age-associated B cells respond to influenza, the research aims to enhance the immune response in elderly individuals, making them less susceptible to new strains of the virus. The approach involves understanding the mechanisms behind these B cells and their ability to produce long-lasting immunity.
Why it matters
Potential benefit: If successful, this research could lead to a more effective influenza vaccine for older adults, significantly improving their protection against the virus.
How similar studies have gone: Other research has shown promise in utilizing age-associated B cells for vaccine development, indicating a potential for success in this novel approach.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Swain, Susan L — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Swain, Susan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.