Developing a new non-hormonal treatment for endometriosis
Official title: Novel, Non-hormonal Therapeutic for Endometriosis
Funded at Endomet Biosciences, INC · NIH-10923897 · Data updated 2026-11-12
This study is working on a new treatment for endometriosis that doesn't use hormones and could actually help improve the condition, giving hope to the 10% of women who live with it.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomet Biosciences, INC NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $999,998 |
| NIH project number | 5R44HD100289-06 |
| Project ID | NIH-10923897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women and adolescents diagnosed with endometriosis who are seeking alternative treatment options beyond hormonal therapies.
✕Less likely to help
Patients who do not have endometriosis or those who have already undergone definitive surgical treatment may not benefit from this research.
What this research studies
This research aims to create the first disease-modifying and non-hormonal therapeutic specifically for endometriosis, a condition affecting about 10% of women globally. The project addresses the limitations of current treatments, which often involve hormonal therapies that can have significant side effects and do not cure the disease. By targeting a specific biological pathway, the research seeks to provide a more effective solution that could alleviate symptoms and potentially reverse the disease process. The approach is innovative and aims to advance to clinical trials, offering hope for better management of this chronic condition.
Why it matters
Potential benefit: If successful, this research could provide a much-needed cure for endometriosis, improving the quality of life for many women and adolescents affected by this condition.
How similar studies have gone: While there have been various approaches to treating endometriosis, this specific non-hormonal therapeutic approach is novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Endomet Biosciences, INC
Irvine, United States Active
Researchers
- Principal investigator: Petrossian, Tanya Christineh — Endomet Biosciences, INC
- Study coordinator: Petrossian, Tanya Christineh
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.