Developing a new method to analyze cell signaling proteins
Official title: A Novel high resolution MS platform for high-throughput screening of G protein-coupled receptors
Funded at Battelle Pacific Northwest Laboratories · NIH-11055999 · Data updated 2026-11-12
This study is looking at new ways to measure how certain proteins in our cells, called GPCRs, work and change, which could help us understand diseases better and improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | June 15, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $480,681 |
| NIH project number | 5R01GM149650-03 |
| Project ID | NIH-11055999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory diseases that involve GPCRs, such as those affecting immune responses.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling or those not experiencing inflammatory diseases may not benefit from this research.
What this research studies
This research focuses on improving mass spectrometry techniques to better understand how certain proteins, specifically G-protein coupled receptors (GPCRs), function in cellular signaling. By using advanced technology, the researchers aim to accurately measure how these proteins are modified through phosphorylation, which is crucial for their activity. This approach could lead to faster and more reliable results compared to traditional methods, ultimately enhancing our understanding of diseases linked to these proteins. Patients may benefit from insights gained about GPCRs, which are common drug targets.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for inflammatory diseases by providing deeper insights into GPCR function.
How similar studies have gone: Previous research has shown promise in using advanced mass spectrometry techniques for studying protein modifications, indicating potential success for this novel approach.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Jacobs, Jon — Battelle Pacific Northwest Laboratories
- Study coordinator: Jacobs, Jon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.