High-throughput multiomic profiling of single cells
Official title: Development of a high-throughput proteomic, transcriptomic, and metabolomic platform for multiomic profiling of same single-cells
Funded at Battelle Pacific Northwest Laboratories · NIH-11428734 · Data updated 2026-11-12
A new platform will measure proteins, RNAs, and metabolites in thousands of individual human cells to better understand how cells regulate themselves.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $492,167 |
| NIH project number | 1R35GM165579-01 |
| Project ID | NIH-11428734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers will work with human cells; patients or patient samples may contribute to studies validating the platform.
✕Less likely to help
Healthy individuals providing samples without disease may not directly benefit from the platform.
What this research studies
This project aims to create a technology that can analyze multiple molecular layers from the same single cell, using innovative chemistry, advanced mass spectrometry, and automated nanodroplet processing. It will enable up to 70 cells per run and will include new data tools to integrate transcript, protein, and metabolite information. Researchers will test the platform on human cells to build more accurate models of cell behavior and regulation. The work combines chemistry, engineering, and bioinformatics to push single-cell multiomics forward. By making these measurements more scalable, it could illuminate mechanisms behind health and disease at the cellular level.
Why it matters
Potential benefit: If successful, patients could benefit from more precise molecular profiling that informs understanding of diseases and informs future therapies.
How similar studies have gone: Similar multiomic approaches exist but this project aims to scale and integrate measurements from the same cell with new chemistry, which is novel.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Fulcher, James Michael — Battelle Pacific Northwest Laboratories
- Study coordinator: Fulcher, James Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.