High-Throughput Lipid Profiling with Precise Structures for Phenotypic Screening
Official title: High Throughput Lipidomic Profiling with High Structural Specificity for Phenotypic Screening
Funded at Battelle Pacific Northwest Laboratories · NIH-11386439 · Data updated 2026-11-12
A project to develop advanced lipid profiling that can precisely identify lipid structures to help understand and screen diseases like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $471,945 |
| NIH project number | 5R35GM156826-02 |
| Project ID | NIH-11386439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals at risk for or living with Alzheimer's disease or related dementias, or participants in biomarker discovery programs involving lipidomics.
✕Less likely to help
People not involved in lipid biomarker research or those without a related condition may not experience direct benefit.
What this research studies
This grant aims to create a next-generation lipidomics pipeline that uses high-resolution mass spectrometry and sophisticated bioinformatics to determine lipid structures in detail. By separating lipid isomers and providing lossless, high-structure data, the work seeks to uncover lipid biomarkers and mechanisms relevant to diseases such as Alzheimer's and diabetes. The approach combines innovative analytical chemistry with computational tools to enable large-scale, phenotype-linked lipid metabolism studies. The goal is to connect specific lipids to biological functions and disease processes, ultimately supporting biomarker discovery and therapeutic insights.
Why it matters
Potential benefit: If successful, patients could benefit from better lipid biomarkers and insights into disease mechanisms that inform diagnosis and treatment strategies.
How similar studies have gone: Prior lipidomics efforts have shown promise in identifying disease-associated lipid changes, but this project aims for higher structural specificity and faster profiling.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Zheng, Xueyun — Battelle Pacific Northwest Laboratories
- Study coordinator: Zheng, Xueyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.