Detection assays for HIV broadly neutralizing antibodies in patient samples
Official title: Detection Assays for Virion Susceptibility to HIV Broadly Neutralizing Antibodies in Plasma and Culture Fluids
Funded at University of Maryland Baltimore · NIH-11518076 · Data updated 2026-11-12
A research project to develop faster tests that detect HIV variants that resist antibody therapies in people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $653,717 |
| NIH project number | 4R33AI176561-04 |
| Project ID | NIH-11518076 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who may be considered for bnAb therapy or enrolled in bnAb-based prevention or cure trials.
✕Less likely to help
If bnAb resistance is widespread or the tests are not applicable to a patient’s sample type, individuals may not benefit.
What this research studies
This project focuses on creating direct tests that measure how well antibodies in a person’s blood or tissues can bind to HIV, helping identify bnAb-resistant viruses quickly. By avoiding lengthy pseudovirus work and sequencing, the team aims to streamline screening for participants in bnAb-based therapies or prevention trials. The goal is to better select participants and monitor resistance, potentially improving outcomes for people with HIV who might benefit from antibody-based strategies.
Why it matters
Potential benefit: If successful, the tests could enable faster, more reliable screening for bnAb therapies and improve accuracy of trial results for HIV prevention and treatment.
How similar studies have gone: Previous efforts show that rapid resistance screening is feasible with direct binding assays, though integrating triple bnAb class testing remains challenging.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Ray, Krishanu — University of Maryland Baltimore
- Study coordinator: Ray, Krishanu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.