Decoding regulatory variants linked to heart disease
Official title: Decoding regulatory variants in cardiovascular disease
Funded at Boston University (Charles River Campus) · NIH-11448792 · Data updated 2026-11-12
A scientist team will study how non-coding genetic changes in heart cells influence cardiovascular disease risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $849,790 |
| NIH project number | 1R01HL181047-01A1 |
| Project ID | NIH-11448792 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cardiovascular disease or those at risk who carry regulatory genetic variants may benefit from future translation of these findings.
✕Less likely to help
Healthy individuals without relevant genetic variants may not directly benefit from this research.
What this research studies
This project looks at how small DNA differences in non-coding regions affect gene regulation in heart cells, which may contribute to heart disease. Researchers will use high-throughput lab methods to map how these variants change the binding of transcription factors and other regulatory proteins. The goal is to connect specific genetic changes to how they alter gene expression in heart tissue, helping us understand why some people are more susceptible to cardiovascular disease. The work involves human-relevant cellular models and genetic analysis to identify mechanisms that could be targeted in future therapies.
Why it matters
Potential benefit: If successful, the study could reveal new targets for treating or preventing cardiovascular disease by correcting or compensating for regulatory genetic changes.
How similar studies have gone: Previous studies have shown that regulatory DNA variants can alter gene expression and contribute to heart disease, but a scalable functional map is still needed.
Where this research is happening
-
Boston University (Charles River Campus)
Boston, United States Active
Researchers
- Principal investigator: Siggers, Trevor — Boston University (Charles River Campus)
- Study coordinator: Siggers, Trevor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.