Creating a tool to predict cognitive performance based on biological age
Development of an epigenetic clock that predicts age-impaired or age-unimpaired cognitive performance
This study is looking at how changes in our DNA can help us understand brain health and memory in older adults, especially those at risk for Alzheimer's, to find better ways to support cognitive function as we age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10510390 on NIH RePORTER |
What this research studies
This research investigates how biological age, as determined by DNA methylation patterns, can predict cognitive performance in older adults. By focusing on the epigenetic changes that occur in the brain, the study aims to differentiate between chronological age and biological age, particularly in relation to Alzheimer's Disease and cognitive decline. Participants may undergo genomic and cognitive assessments to help identify the mechanisms behind age-related cognitive impairment and potentially lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those experiencing cognitive impairment or at risk for Alzheimer's Disease.
Not a fit: Patients who are younger than 65 or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting cognitive decline and developing targeted interventions for Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in using epigenetic clocks to assess biological age, but this specific approach focusing on cognitive performance in the brain is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Wood, Marcelo Andres — University of California-Irvine
- Study coordinator: Wood, Marcelo Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.