Creating a mouse model to study low back pain from disc degeneration
Official title: Development and Validation of a Mouse Model of Intervertebral Disc Degeneration-Induced Low Back Pain to Facilitate Non-Addictive Analgesic Discovery
Funded at University of Minnesota · NIH-11040422 · Data updated 2026-11-12
This study is creating a special mouse model to better understand low back pain from worn-out discs, which could help find new, safer ways to relieve pain for people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $774,930 |
| NIH project number | 1R61NS136569-01A1 |
| Project ID | NIH-11040422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic low back pain attributed to degenerating intervertebral discs.
✕Less likely to help
Patients with low back pain due to causes other than intervertebral disc degeneration may not benefit from this research.
What this research studies
This research aims to develop a mouse model that accurately mimics the biological processes of low back pain caused by degenerating intervertebral discs. By using a specific genetic modification technique, the researchers will create a model that allows for the gradual degeneration of discs, similar to what occurs in humans. This model will help in understanding the mechanisms behind discogenic low back pain and facilitate the discovery of new, non-addictive pain relief therapies. The study focuses on ensuring that the model does not have unintended effects on other body tissues, which is crucial for accurate results.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective non-addictive pain relief options for patients suffering from low back pain.
How similar studies have gone: Previous research has shown promise in developing animal models for studying low back pain, but this specific approach is innovative and aims to improve upon existing models.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Stone, Laura S — University of Minnesota
- Study coordinator: Stone, Laura S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.